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However, it may also worsen liver disease and was found to cause liver cell death and liver damage, further demonstrating how dangerous it is, . In one study, the activation of PPAR-delta via cardarine drove the development of muscle fibers in mice. These muscle fibers were associated with increased physical performance: the treated mice had improved endurance and could run for almost twice as long [17]. Limited research suggests that activation of PPAR-delta could improve the inflammation caused by skin diseases like psoriasis.